Analysis of the association of IL1RN gene allelic polymorphism with the development of arterial hypertension

The contribution of polymorphic markers rs2234663 (VNTR) and rs419598 (c.2008T>C) the IL1RN gene to predisposition development arterial hypertension among population Karelia was studied. occurrence alleles genotypes for these almost same in group healthy people patients with (χ2 = 0.178, p 0.67; χ2 0.540, 0.76; 0.01, 0.93, 1.68, 0.43, respectively rs419598). level IL-1β IL-1α plasma did not depend on carriage allelic variants gene. number transcripts intercellular adhesion molecule ICAM1 higher peripheral blood leukocytes individuals A1A1 genotype TT compared carriers alternative (p < 0.05). content soluble form ICAM (sICAM) than A1A2 A2A2 0.02). Thus, no association detected between VNTR c.2008T>C risk developing inhabitants Republic Karelia. Nevertheless, observed effect sICAM suggests that loci may be involved steadily high pressure, probably through regulation vascular endothelial functions